Pityriasis Rosea Research
Welcome. We are the makers of PrrEze, the world’s first effective relief for pityriasis rosea. PR as most people call is nasty, ugly, itchy and depressing. Most people have it for 8 to 12 weeks. Most people only have it once in their life time. Most people only have mild itch and discomfort. Those sound like very nice things unless you are the one suffering.
We have found out a lot since we began making PrrEze, and further along we will tell our story. The main thing we have found is that most people who have PR and go to a doctor leave with nothing but a bill and some steroids that help nothing. Most doctors do not have empathy for what you are going through. They tell you things like “it will resolve by itself”, “It is not that bad, really”, “it will be gone in a few weeks, it’s ONLY a rash”, “it doesn’t have a bad outcome, doesn’t lead to SERIOUS disease”. I wish each and every one of those doctors suffered with pityriasis rosea for “just a few weeks”.
Our data shows that most people diagnosed with PR are diagnosed without a biopsy. About 30 percent of those diagnosed without a biopsy by a general practitioner or emergency room are misdiagnosed. About 15 percent diagnosed by a dermatologist without a biopsy are misdiagnosed. If you go on Google and self diagnose from pictures and symptoms, without all those years in medical school your chances of misdiagnosing are about 40 percent, so your guess is only 10 percent worse than a doctor’s!
You want to know what this rash is, how you got it, and why you got it. At the moment it is not yet known for sure. PR is a rare rash. It is probably not contagious. There is a recent study out that suggests that it may be contagious, BUT in about 20,000 clients, we have only heard 4 people say anyone around them got it. It is not deadly. It does not lead to worse diseases. You only get it once (with very rare exceptions). This makes it basically uninteresting to medical science, as well as difficult to study. Think about it this way: About a million cases a year are reported worldwide. There are between 10 and 15 million doctors in the world. The odds are that A doctor may see A case every 3 to 5 years. Difficult to study a disease that way. The latest studies point to a possible link to a virus, possibly herpes 6 or maybe 7 (think rash, not an STD). We are sure you have heard of shingles. That has been linked to chicken pox, which is also a herpes virus. It is estimated that over 99% of the world’s population has had HHV-6 (human herpes virus-6). The virus is in your system, and little bits of it stay there for life. For most people nothing else ever happens. HHV-6 may be the cause, but not the trigger. It needs a trigger to “pop out” of its routine of just being in the background. Researchers think this may be stress, whether physical or mental. It may be something as small as bumping your wrist on a doorknob, or as traumatic as a car accident. Tripping down the stairs, breaking a bone, bumping your head, dental procedure, surgery, pregnancy, a new medication, a new deodorant, a new chemical on clothing from the dry cleaners…. Hundreds of possibilities. On the mental side it could be death in the family, relationship breakup, upcoming exams, worldwide pandemic.. Why you? Wish we knew!
How do you KNOW you have PR? We are on a rant here: GET A BIOPSY!!!! You are the one paying for your medical care. Whether you pull your credit card, cash, or check out and pay on the spot (or pay your deductible) or whether you pay your insurance and the insurance pays the doctor, that money comes from YOUR pocket. You DESERVE to KNOW what is wrong with you, rather than be foisted off with a guess. You are PAYING to KNOW what is wrong with you. A scrape biopsy will tell you which one of many rashes you have. It could be PR, which is wonderful, comparatively speaking, because for most people it only happens once, and it goes away. There are at least 5 rashes that look very similar to PR, in early stages. 1) contact dermatitis. A low grade allergic reaction that can go on for months without ever getting to the "anaphylaxis" stage. Try Benadryl as directed for 3 days, if rash gets better, you know what it is. 2) Ringworm try any antifungal- a jock itch spray or athlete's foot spray- for 3 days, if it helps, you know what you have. 3) Lichen planus, a close cousin of PR, it does affect hands, feet and face, and is a lifetime disease, that ebbs and flares, like psoriasis does. PrrEze will help, but it will take 4 to 6 weeks to handle the rash, and you won't see any improvement for at least 2 weeks. You may see skin peeling lightly, but no pain or burning sensation. We make LichensEze especially for it, but PrrEze will work. 4) guttate psoriasis, another lifetime, and another that will show on your face. PrrEze will help, but it takes weeks to do it. 5) Granuloma anulare, a very rare one that even we do not know a lot about.
There are very few things that are “ah ha” about PR. There is USUALLY a “herald patch” that means a patch that shows up weeks or even months before the rest of PR does and “heralds” the approach of the rash. You may or may not have even noticed it, they usually do not even itch. If you did notice it, you might have thought it was a bad bug bite. Then the rash shows up. It starts to spread. About 30% of people who have PR report no itch. About 60% of people report mild to moderate itch. About 10% report horrible, itch that makes you want to pull your skin off. So that is not a good way to guess what you have. PR is ALWAYS a dry rash. If there is any liquid in any part of your rash, you do not have PR. As it spreads, it USUALLY makes ovals that are completely flat and smooth inside with a slightly raised edge that feels dry, but does not flake off or anything. The spread of PR can be out from where it started, but it can also be in “pop ups”- you have rash on your torso, and suddenly there is a patch on your shin, without any connecting rash. Of the million people or so a year who get PR, only about 100 get PR that spreads to your face, hands or feet. Of the million people a year who get PR only about 100 people a year get PR a second time. Of the million or so people who get PR in a year, only about 100 have PR that lasts more than 12 weeks. I was diagnosed with a biopsy as having PR, mine was a rare form called “gigantea”. I was diagnosed at month 9. SO, I had at least 2 whammies. Mine was scalp to wrists, neck to ankles, in my mouth, in my ears….but not on face, hands or feet. However, when a client says their PR is all over their face, I tell them to go get a biopsy. It is that rare. We have had over 20 THOUSAND clients in the past 5 years. No, I cannot tell whether it is PR just by looking at it or pictures of it.
We have sold over twenty thousand containers of PrrEze to customers all over the world. Our product has no chemicals, no harsh ingredients, and is all food grade. That means you could eat it. We guaranty it does not taste good, but every ingredient is approved by the FDA as safe for human consumption. It does not require a prescription, and we have not found a single country that has a problem with the basic ingredients. Our labels conform to FDA standards, and we proudly list all our ingredients in plain English. You will probably find most of them in your kitchen… we did!
Our data shows that PrrEze is proven effective in over 97.4 percent of biopsied cases of pityriasis rosea. What happens when you use PrrEze? If you actually have PR you will have mild to demonic itching and will do just about anything to get rid of that itch! PrrEze usually takes away that itch within about 20 minutes. We advise that you put it on twice a day- morning and evening, but you are welcome to use it as often as you want. We use it as a daily moisturizer. Doctors we have consulted have told us that all the ingredients in PrrEze are “inert” so they cannot “do” anything for PR. You will find out differently, just as we did. By day 2 or 3 at the latest, your rash will turn red. You will panic (we did) and think you have an infection or allergic reaction. You do not. Skin that is not affected by the rash does not turn red, only the rash itself turns red. By day three or four the rash is starting to dry up and flake off- think dandruff flakes, not sunburn peel. For most people the rash is gone and skin is smooth within a week. It may or may not leave behind hyperpigmentation- spots that may be lighter or darker than the surrounding skin. This is NOT scarring. It will fade to skintone within weeks, and is the same whether you use PrrEze or not. This spotting is NOT considered a “part” of the rash, and is NOT included in the doctor’s 8 to 12 weeks timeframe either.
How can our formula be so effective and doctors not tell you about it? Because PrrEze is not considered a “medicine” or a “drug” doctors are not supposed to tell you about it just in case you decide to sue them for suggesting it. Doctors who have looked at it simply say that it can’t “do” anything because all the ingredients in it are not “medicines”. They probably say the same thing about willow trees (aspirin), belladonna (atropine) and the Pacific yew tree (Taxol) just to name a few. We will describe our ingredients and what they do shortly.
We have the world’s largest database on PR. We answer at least 30 client questions a month. We interact with people who believe they have PR, who then tell us how well PrrEze is working or not working for them. As we mentioned earlier, PrrEze is proven effective in over 97% of biopsied cases.
We hope this information has helped to calm you and ease your fears about PR. We know it is nasty. Many people get very depressed because they cannot wear short sleeves or shorts or bathing suits. They worry about what people may think. During the pandemic, even more people have gotten depressed because their friends/coworkers/the public at large looks at the rash and freaks out, thinking it is contagious. We are certainly NOT going to tell you to “just deal with it”. We are going to tell you to get some PrrEze. You cannot fix stupid people, nor is it worth your time to try to explain your rash to them. Depression is not nice to deal with, and the easiest way to “cure” the depression is to get rid of the rash that is causing it. We ship with FedEx 2 day Express, and Express International. FedEx is the next best thing to having a teleporter! We can get PrrEze to you in the US in 2 days (except Sundays), and anywhere else in the world in 3 to 5 business days!!!!! Trust us, we have tried every other shipper, and this is fastest, regardless of dollars spent. I guess you could have a courier come get it and fly it to you via private jet, it just hasn’t happened yet! You are welcome to ask us to do that for you! (Buyer pays all shipping costs).
Our story: Frank had brain cancer (in remission 6 years, thanks!!!!), I got an ugly rash. I am pretty self sufficient. Looked like ringworm, so I got some antifungal. Nothing. At a Frank doctor appointment, his GP concurred that it was ringworm, so he gave me some oral antifungals. Nothing. We were kinda busy with Frank- surgery, rehab, radiation, learning to walk again…. Doctors 5 days a week. Rehab 5 days a week. He couldn’t get out of bed by himself for about 6 months. No stress, right? My PR was just mildly itchy- enough to make it uncomfortable, and harder to go to sleep, enough to make me irritable- although I tried VERY hard not to be, because Frank was in a LOT worse shape…. Finally, at month 9 of my PR I went to a dermatologist… It was a multi doctor practice. The doctor assigned to me looked at my arm. Asked where else it was. I told her it was neck to ankles to wrists, in my mouth, scalp, ears…. She asked whether I would mind stripping. Nope. (Frank was in the room with me). She asked whether I would mind if she “consulted” with the other doctors.. Nope. 5 of them came in, so I was naked, and observed by 6 doctors. They whispered behind their hands. They picked up an arm to look more closely. This might have been more fun for me or perhaps for them if I was NOT over 50, overweight, and a mother of three… 5 doctors left. The one that was left (the original one) said they would do a biopsy to make sure, but she did NOT THINK IT WAS CANCER….. REALLY?????? You had to lead with that. Frank was freaking out (as you can imagine). After what we had been through with him over the past year, no-one should have uttered the “C” word without knowing it was a distinct possibility. We asked what they thought it was, and got, “hard to say, that is why we are doing the biopsy”. That should have been the only thing said, plus the “we are doing the biopsy because we don’t know”. Scrape biopsy was done on about 5 of the spots of rash.
We waited.. and waited.. Frank was beside himself. He was hovering. He was upset. Finally, after a week, we got a PHONE CALL… The office person who called said you have pityriasis rosea gigantea. Yes, I did ask what it was a second time, and asked her to spell it for me, so I could go to Google. We’re calling in a prescription for some steroids for you. I asked when my next appointment was, would the steroids make the rash go away, how long would it take….. Nope. No appointment, nothing they had that would help, and “it will resolve by itself”… WHEN????????????????? Usually in 8 to 12 weeks… IT HAS BEEN 9 MONTHS…… Well, sometimes that happens. Click. So much for doctors.
Google was not very helpful, but it did have some forums where people commiserated with each other and said that dandruff shampoo helped. Tried it. It made my skin very dry, itch was worse, it did dry the rash, but it did not make it go away. Someone else said that black soap was great. Nope. Vitamin D and garlic. Nope. Turmeric paste. Nope. I tried everything that anyone recommended. Went to a Chinese doctor for herbals. Nope. Googled Ayurveda. Nope. I did have some aloe plants, so I spread some aloe gel on it, and that calmed the itch a little. Because of the Chinese herbs and the Ayurveda I found out a lot about natural plants and what they have in them and what they do. I started putting stuff from the kitchen in the blender. Put magic marker marks on me and kept notes. Some stuff worked better than other stuff, so I kicked out what didn’t work and added more stuff to things that did help with itch or redness. I was home with Frank, so I didn’t have anything better to do. One day, I woke up and one of my “magic circles” or stuff I had concocted was bright red…. Yeah, My thought was, “OK, Veesha, you really did something stupid this time, you gave yourself an infection or something”…. I was too embarrassed to go to the emergency room, so I called the GP. (Same GP who had seen us though many things the past year). He said, OK, sounds as though you did something stupid, take some Benadryl, come see me day after tomorrow, if it gets worse, go to the emergency room anyway. By day after tomorrow, redness was gone, and rash was dry, but the skin around it was not. Being a completely logical person (nope) I immediately put some of that concoction in another area. Sure enough, day 2 red, day 4 dry and flaking off. Itch was not there either!!!!! I had Frank slather it on me everywhere I could not reach, and in the middle of month 14 I was PR free!!!!! The only good thing that came of my PR was it lasted so long I had a lot of skin and a lot of time to experiment. I went on some of the forums that had sustained me in my misery, and told people I had something that might help, and would anyone like to try it? I sent the oily mess to them, and all of them said it turned their rash bright red by day 2 or three, and by day 4 or 5 it was no longer red, and was flaking off. I turned to Frank, and told him we were going to “sell this stuff”…. He (wonderful man that he is) said, “Yes, Dear.” So, our company was born! I went to Walmart and bought some mini mason jars (4 ounce), and started trying to make a bunch of oils into something manageable without using nasty chemicals. It is harder than you think! I am not a chemist nor a scientist of any kind, so, for me, it was even harder. Not like we had money to hire someone, and I certainly did not want to start with somebody else’s formula of cream that you can add your own stuff to (same reason, may not work). We tried a bunch of stuff. Finally settled on powdered konjak root (a thickener) and natural beeswax (a stabilizer). It worked well, except in summer, when it got so hot that it melted in transit and separated so wax was on top, and a gooey mess was underneath. People bought it and used it anyway- yeah, we know we will do just about anything to get rid of the rash. People were also very kind. They said things like “it’s kinda gross to use, very oily, smells very strong (flowery, not mediciny) but it works”…. We’ve been selling it for over 5 years now. We switched to really cute cobalt blue jars about 4 years ago. With Covid, many things like packaging are simply not available. The wonderful people we buy jars from had no stock. Of any size. In any color. For months. We had to regroup. I found bottles. Cream does not do well in bottles, because it will not come out of them. We reformulated. Tried something called lecithin. It allowed us to make lotion that comes out of the bottles! (no, it was not the first, or even the 10th attempt).
When we started, we sent stuff with the US Postal Service. They were wonderful, but international shipments were expensive, slow, and many got held up in customs for weeks. We then tried UPS… Faster, better on internationals, but expensive, and they nickel and dimed us for everything. FedEx was next. AWESOME!!!! They send paperwork ahead of packages to customs, and they have an agent assigned so packages are expected and picked up promptly. Domestic packages get there FAST too.
Ingredients and what they do: PrrEze is all natural. It has no known side effects. All ingredients are food grade. Why are the ingredients in PrrEze in there? Easy answer is because they work! Let's look at a rundown:
Aloe vera: From Baylor College of Medicine: “It contains antioxidants, enzymes, Vitamins A and C, and it is highly anti-inflammatory. “
Corn oil: From www.oilhealthbenefits.com : “Immunostimulant – Corn oil provides essential fatty acids like linoleic acid ( omega – 6 ) which is required for some immune system functions. Antioxidant – Corn oil contains Vitamin E which is an antioxidant. It improves skin functioning because of the presence of linoleic acid and vitamin E in it. Corn oil is about 59 % linoleic acid and because of it, this oil penetrates quickly into the skin. “
Canola oil: from www.lybrate.com:
“Canola oil is rich in vitamin E and K, which helps to eradicate skin problems like wrinkles, fine lines, acne, blemishes etc. and give a youthful shiny skin to individuals. Vitamin E is very effective as an antioxidant, and is able to protect the skin from the damaging effects of free radicals. This can help skin remain supple and smooth, increasing the healing rate of injuries, and slowing down the appearance of wrinkles. “
Coconut oil: from www.healthline.com:
Lauric acid: 49%
- Myristic acid:18%
- Caprylic acid:8%
- Palmitic acid:8%
- Capric acid:7%
- Oleic acid:6%
- Linoleic acid:2%
- Stearic acid:2%
The medium-chain fatty acids in coconut oil have antimicrobial properties that can help protect against harmful microorganisms.
This is especially important for skin health, as many types of skin infections, including acne, cellulitis, folliculitis and athlete's foot, are caused by bacteria or fungi (6).
Applying coconut oil directly to the skin may prevent the growth of these microorganisms.
This is due to its lauric acid content, which makes up nearly 50% of the fatty acids in coconut oil and can fight harmful microorganisms.
One study tested the antibacterial properties of 30 types of fatty acids against 20 different strains of bacteria. Lauric acid was found to be the most effective at blocking the growth of bacteria (7).
Another test-tube study showed that lauric acid can kill off Propionibacterium acnes, a type of bacteria that leads to the development of inflammatory acne (8).
Furthermore, capric acid is another medium-chain fatty acid found in coconut oil, although to a lesser extent. Like lauric acid, capric acid has been shown to have potent antimicrobial properties.
A test-tube study showed that both lauric and capric acid effectively killed off strains of bacteria (9).
Another test-tube study demonstrated the anti-fungal effects of capric acid, showing that it was able to inhibit the growth of certain types of fungi (10).
Chronic inflammation is a major component of many different types of skin disorders, including psoriasis, contact dermatitis and eczema (11).
Interestingly, coconut oil has been shown to have anti-inflammatory properties.
In one study, researchers applied virgin coconut oil to the inflamed ears of rats. Not only was coconut oil found to have an anti-inflammatory effect, but it relieved pain as well (12).
What's more, coconut oil may ease inflammation by improving antioxidant status.
A 2013 animal study fed rats different types of oil, including coconut oil, olive oil and sunflower oil. At the end of the 45-day study, virgin coconut oil had improved antioxidant status and prevented oxidative stress to the greatest extent (14).
It's important to keep in mind that most current research is limited to animal and test-tube studies, so it's hard to know how these results may translate to humans.
However, based on these studies, coconut oil shows great potential in its ability to reduce inflammation when consumed or applied to the skin.
While some think coconut oil clogs pores, considerable research shows it might actually help treat acne.
Acne is an inflammatory condition, and many of the medications used to treat it work by targeting and reducing inflammation (15).
Because coconut oil and its components may help reduce inflammation in the body, it may also aid in the treatment of acne.
Furthermore, the antibacterial properties of the medium-chain fatty acids in coconut oil could also help reduce acne.
In fact, test-tube and animal studies have shown that lauric acid is more effective than benzoyl peroxide at preventing the growth of acne-causing bacteria (16).
Along with lauric acid, capric acid has been shown to have anti-inflammatory and antibacterial properties.
A 2014 animal and test-tube study showed that both lauric and capric acid were successful in reducing inflammation and preventing acne by killing off bacteria (17).
To get the best results, coconut oil should be applied directly to the skin in areas where acne is found
One study in patients with mild to moderately dry skin compared the effects of coconut oil to mineral oil, a type of oil made from petroleum that's often used to treat dry skin.
The two-week study found that coconut oil significantly improved skin hydration and was just as effective as mineral oil (18).
It has also been shown to help treat eczema, a skin condition characterized by scaly, itchy rashes.
A study comparing the effects of olive oil and coconut oil in 52 adults with eczema found that applying coconut oil helped reduce dryness, in addition to helping treat eczema (19).
Another study found similar results, showing that coconut oil led to a 68% decrease in eczema severity, making it significantly more effective than mineral oil in the treatment of eczema (20).
Several studies have demonstrated that coconut oil may also aid wound healing.
One animal study looked at how coconut oil applied to the skin affected wound healing in rats.
Another animal study showed that coconut oil combined with an antibiotic applied to the skin was effective at healing burn wounds (25).
In addition to improving wound healing, its antimicrobial properties may also prevent infection, one of the major risk factors that can complicate the healing process (26).
Grapeseed oil: from www.healthline.com “This oil is known for its anti-inflammatory, antimicrobial, and anti-oxidant properties.
These properties, along with the high amounts of omega chain fatty acids and vitamin E contained in grapeseed oil, have made it a popular topical treatment for skin.”
Beeswax: from www.livestrong.com: “, beeswax offers anti-inflammatory, antibacterial and antiviral benefits. Beeswax may have mild antibacterial properties, according to a 2005 study conducted at Dubai Specialized Medical Center in the United Arab Emirates.
Olive oil: from www.medicalnewstoday.com : antioxidant, antibacterial, and contains vitamins A,D,E and K
Walnut oil: from www.medicaldaily.com: “ has hefty levels of vitamins B-1, B-2, and B-3, coupled with vitamin-E and niacin. Certain phytonutrients and fatty acids in walnut oil can contribute enhancing the texture and quality of the skin. Prevents eczema: walnut oil can be beneficial for people suffering from the skin rashes called eczema. Walnuts and walnut oil are also rich in antioxidants
Sesame oil: From www.livestrong.com : Massaging the skin with sesame oil is common in Indian medicine, which claims that it improves skin’s texture and elasticity. Because the oil is high in antioxidants, it can also speed wound healing when applied directly to cuts and scrapes. These antibacterial properties have also proven effective for some who suffer from skin ailments, such as eczema or psoriasis.
Sesame seed oil has inflammatory, antibacterial and anti-fungal properties
Geraniol oil: from www.ayurvedicoils.com : “Geraniol serves as an analgesic to relieve the pain. It is also a topical drug enhancer. Apart from the above uses of Geraniol, it also has the following health benefits. Geraniol has antibacterial, antiseptic, anti-inflammatory properties. “
Sunflower oil: from www.dermatologytimes.com : “Sunflower seed oil is rich in linoleic acid, and has been used topically in the treatment of essential fatty-acid deficiency, rapidly reversing the disease with its excellent transcutaneous absorption.[iii] More locally, these essential fatty acids can help maintain the skin barrier and decrease transepidermal water loss, both important features in thinking about skin problems such as atopic dermatitis.[iv] There is some thought that preparations with higher amounts of linoleic acid versus oleic acid may be more beneficial in this role and some clinical data that bears this out.[v]
Several studies have also suggested that sunflower seed oil has anti-inflammatory properties. Linoleic acid is the major lipid that converts to arachidonic acid, which leads to prostaglandin E2, an inflammatory modulator, possibly via peroxisome proliferative-activated receptor-a (PPAR-a) activation. These anti-inflammatory aspects are very compelling for our menagerie of inflammatory dermatoses. "
Safflower oil: from www.healthline.com :”safflower oil may have pain-relieving effects, as well as anti-inflammatory and antioxidant benefits.”
Hemp derived CBD oil: From Helathline.com: Moisturizes and soothes inflammation
One of the omega-6 fatty acids that hemp oil contains is gamma-linolenic acid (GLA), which acts as a powerful anti-inflammatory while simultaneously encouraging skin growth and new cell generation.
This can help to calm inflammation and irritation on the skin, including acne and some conditions like psoriasis, while keeping the skin nourished and moisturized.
Lemongrass: from www.healthline.com : 1. It has antibacterial properties
Lemongrass is used as a natural remedy to heal wounds and help prevent infection. Research from 2010 found lemongrass essential oil was effective against a variety of drug-resistant bacteria including those that cause:
Antifungal: Fungi are organisms like yeast and mold. According to an older study from 1996, lemongrass oil was an effective deterrent against four types of fungi. One type causes athlete’s foot, ringworm, and jock itch.
Antiinflamatory: Chronic inflammation is thought to cause many health problems. These include arthritis, cardiovascular disease, and even cancer. Lemongrass contains citral, an anti-inflammatory compound.
According to a 2014 study on animals, oral lemongrass essential oil showed powerful anti-inflammatory abilities on mice with carrageenan-induced paw edema. The oil also demonstrated anti-inflammatory effects when applied topically on mice with ear edema.
Antioxidant: Antioxidants help your body fight off free radicals that damage cells. Research has shown that lemongrass essential oil helps hunt free radicals.
Yeah, who knew? I did after lots of research. I looked at traditional western medicine, ayurvedic medicine and Chinese traditional medicine. Read every hint I could find about natural oils and rashes, and tried them all one by one and in bunches. What we achieved was a cream very high in antibacterial, antifungal, antiviral, and anti inflammatory oils. You do not need a prescription. This cream is safe on babies, safe for delicate skin, safe for nursing mothers, and generally safe for everyone. Avoid this cream if you are allergic to any of the ingredients!